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Research>Groups>Medical Microbiology Section>Immunology>Laboratory Osterloh

Department of Immunology/LG Osterloh

 


 

Head
Dr. Anke Osterloh
Bernhard-Nocht-Institute
for Tropical Medicine
Bernhard-Nocht-Str. 74
D-20359 Hamburg
Germany

Tel.: +49-40-42818-840
Fax: +49-40-42818-400


Scientific Staff
Dr. Birte Kretschmer
Melanie Uhde
Stefanie Papp

 

Support Staff
Ulricke Richardt
Svenja Kuehl

 


Overview

 


Projects

 


Selected Publications

 


Overview

 

 

The transmembrane glycoprotein CD83 functions as an inhibitor of B lymphocytes that interferes with proliferation, antibody production and early BCR-mediated signaling events such as calcium influx. Since January 2009 we are now analyzing the mechanisms by which CD83 mediates its inhibitory effect. Since the short intracellular domain of CD83 lacks any known signaling motifs we suppose that CD83 functions via the interaction with other regulatory molecules on the B cell surface or on other cells. Therefore one focus of our work is the identification of potential interactions partners of the CD83 molecule that could contribute to its inhibitory function. Furthermore we are analyzing intracellular signaling events that are modulated by the presence or absence of CD83.

 

Projects

 

Regulation of B cell activation by CD83



Selected Publications
 

Osterloh A, Geisinger F, Piédavent M, Fleischer, Brattig N, Breloer M (2009): Heat shock protein 60 (HSP60) stimulates neutrophil effector functions. Accepted by the Journal of Leukocyte Biology

Kretschmer B, Lüthje K, Ehrlich S, Osterloh A, Piedavent M, Fleischer B, Breloer M (2008): CD83 on murine APC does not function as a costimulatory receptor for T cells. Immunol Lett 120:87-95

Kretschmer B, Luthje K, Ehrlich S, Osterloh A, Piedavent M, Fleischer B, Breloer M (2008): CD83 on murine APC does not function as a costimulatory receptor for T cells. Immunol Lett 120:87-95

Osterloh A, Veit A, Gessner A, Fleischer B, Breloer M (2008): HSP60-mediated T cell stimulation is independent of TLR4 and IL-12. Int Immunol 20:433-43

Osterloh A, Breloer M (2008): Heat shock proteins: linking danger and pathogen recognition. Med Microbiol Immunol 197:1-8

Osterloh A, Kalinke U, Weiss S, Fleischer B, Breloer M (2007): Synergistic and differential modulation of immune responses by HSP60 and lipopolysaccharide. J Biol Chem 282:4669-80

Osterloh A, Meier-Stiegen F, Veit A, Fleischer B, von Bonin A, Breloer M. (2004): Lipopolysaccharide-free heat shock protein 60 activates T cells. J Biol Chem 279:47906-11

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Edited 08/2011


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