Research>Groups>Medical Microbiology>Research Group Breloer (Helminth Immunology)

BRELOER GROUP
Helminth Immunology

 
 
 

Head
PD Dr. Minka Breloer
Bernhard Nocht Institute
for Tropical Medicine
Bernhard-Nocht-Str. 74
20359 Hamburg
Tel.: +49 (0)40 42818 830
Fax: +49 (0)40 42818 400

Scientific Staff
Dr. Wiebke Hartmann (-840/-833)
Birte Blankenhaus (-832/-833)
Irma Haben (-832/-833)
Manchang Tanji Kingsley (-832/-834)

Associated Scientist
Dr. Nadia Ben Nouir (until 10-2011)

Support Staff
Marie-Luise Eschbach (-833)


  It is estimated that more than one third of the world population is infected with parasitic helminths. As helminth infections often result in the modulation of the host's immune response, this has an important impact on the ability of infected people to mount successful immune responses to concomitant infections or to respond to vaccinations. We employ the experimental models of murine Strongyloides ratti and Litomosoides sigmodontis infection to analyze the immune response to pathogenic nematodes with a special focus on regulatory receptors, regulatory cytokines and regulatory cell populations. Within these models we describe modulation of the host immune response to bystander antigens and intend to investigate the underlying mechanisms.

 

Projects

 
  • Role of regulatory T cells and regulatory receptors in the immune response to Strongyloides ratti

  • Modulation of the immune response to bystander model antigens in Strongyloides ratti and Litomosoides sigmodontis infected mice

  • Role of Nematode-derived ES products in immune response and immune modulation
    Dr. N. BenNouir, M.T. Kingsley

For previous work concerning the role of CD83 and Hsp60 in the regulation of immune responses see Laboratory Breloer / Deptartment of Immunology
   

 

Publications

 

Ben Nouir N, Eschbach M-L, Piédavent M, Osterloh A, Kingsley MT, Erttmann K, Brattig N, Liebau E, Fleischer B and M Breloer
Vaccination with Strongyloides ratti Heat Shock Protein 60 increases susceptibility to challenge infection by induction of Th1 response
Vaccine 2011 in press

Kolbaum J, Tartz S, Hartmann W, Helm S, Nagel A, Heussler V, Sebo P, Fleischer B, Jacobs T, and M Breloer
Nematode-Induced Interference with anti-Plasmodium CD8+ T cell response can be overcome by optimizing Antigen Administration
Eur. J. Immunol 2011 in press

Hartmann W, Haben I, Fleischer B and M Breloer. 2011
Pathogenic nematodes suppress humoral responses to third party antigens in vivo by IL-10 mediated interference with T helper cell function
J. Immunol. 2011 Aug 10 in press

Hartmann W, Eschbach ML and M Breloer. 2011
Strongyloides ratti infection modulates B and T cell responses to third party antigens
Exp Parasitol. 2011 Jun 23 in press

Blankenhaus B, Klemm U, Eschbach ML, Sparwasser T, Huehn J, Kühl AA, Loddenkemper C, Jacobs T, and M Breloer. 2011
Strongyloides ratti infection induces expansion of regulatory T cells that interfere with immune response and parasite clearance in BALB/c Mice
J Immunol. 2011 Apr 1;186(7):4295-305

Kolbaum J, Ritter U, Zimara N, Brewig N, Eschbach ML, and M. Breloer. 2011
Efficient control of Leishmania and Strongyloides despite partial suppression of nematode induced Th2 response in co-infected mice.
Parasite Immunol. 2011 Apr;33(4):226-35.

Kretschmer, B., Kühl, S., Fleischer, B. and M. Breloer. 2011
Activated T cells induce rapid CD83 expression on B cells by engagement of CD40.
Immunol Lett. 2011 May;136(2):221-7

Eschbach, M.L., Klemm, U, Blankenhaus, B., Kolbaum, J., Brattig, N., and M. Breloer. 2010
Strongyloides ratti infection induces transient nematode-specific Th2 response and reciprocal suppression of IFN- production in mice.
Parasite Immunology 32(5): 370

Kretschmer, B., Lüthje, K., Schneider, S., Fleischer, B., and M. Breloer. 2009
Engagement of CD83 on B cells modulates B cell function in vivo.
J. Immunol. 182: 2827

Kretschmer, B., Lüthje, K., Ehrlich, S., Osterloh, A., Piedavent ,M., Fleischer, B.
and M. Breloer. 2008
CD83 on murine APC does not function as a costimulatory receptor for T cells.
Immunol. Letters 120: 87

Lüthje, K., Kretschmer, B., Fleischer, B. and M. Breloer. 2008
CD83 regulates splenic B cell maturation and peripheral B cell homeostasis.
International Immunol. 20: 949

Kretschmer, B., Lüthje, K., Guse ,A. H., Ehrlich, S., Koch-Nolte, F., Haag, F., and M. Breloer. 2007.
CD83 modulates B cell function in vitro: increased IL-10 and reduced Ig secretion by CD83tg B cells.
PloS ONE 2 (8): e755

Breloer, M., Kretschmer, B., Luthje, K., Ehrlich, S., Ritter, U., Bickert, T., Steeg, C., Fillatreau, S., Hoehlig, K., Lampropoulou, V. and B. Fleischer. 2007
CD83 is a regulator of murine B cell function in vivo.
Eur J Immunol. 37: 634

Lüthje, K., Cramer, S.O., Ehrlich, S., Veit, A., Steeg, C. Fleischer, B., von Bonin A. and M. Breloer. 2006
Transgenic expression of a CD83 immunoglobulin fusion protein impairs the development of immune competent CD4 positive T cells.
Eur J Immunol 36: 2035

Osterloh, A., Geisinger, F., Piedavent, M., Fleischer, B., Brattig, N., and M. Breloer. 2009
HSP60 stimulates Neutrophil effector functions.
Journal of Leukocyte Biology. 2009

Osterloh, A., Veit, A., Gessner, A., Fleischer, B. and M. Breloer. 2008.
Hsp60-mediated T cell stimulation is independent of TLR4 and IL-12.
Int Immunol. 20: 433

Osterloh, A., Kalinke, U., Weiss, S., Fleischer,B. and M. Breloer. 2007
Synergistic and differential modulation of immune responses by Hsp60 and LPS.
J Biol Chem. 282: 4669

Reviews
 

Breloer, M. and B. Fleischer 2008.
CD83 regulates lymphocyte maturation, activation and homeostasis.
Trends Immunol. 29: 186

Osterloh, A. and M. Breloer. 2008.
Heat shock proteins: linking danger and pathogen recognition.
Med Microbiol Immunol. 197: 1


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Last update: 09/2011

 

 


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